Epilepsy and mood

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Mood disorders in patients with epilepsy.

Epilepsy is a common disabling neurological disorder associated with increased rates of mood disorders especially depression as compared to the general population. Most antidepressants at therapeutic dosages exhibit a seizure risk. Some antidepressants may also display antiepileptic effects, especially at low doses, but the mechanism of this action is largely unknown. In general, the new antide...

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Interictal mood and personality disorders in temporal lobe epilepsy and juvenile myoclonic epilepsy.

BACKGROUND Mood disorders have been described as the commonest psychiatric disorders in patients with temporal lobe epilepsy. Secondary depression in temporal lobe epilepsy could be interpreted either as an adjustment reaction to a chronic disease or as a limbic dysfunction. To clarify this issue, a controlled study of psychiatric disorders was conducted in different forms of epileptic and non-...

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Mood disorders in epilepsy - diagnostic and methodological considerations.

BACKGROUND Mood disorders are common in people with epilepsy (PWE) with prevalence rates ranging from 11% to 62%. The variation in epidemiological data results probably from the diversity of methodologies employed and selection of the populations across the studies. Moreover, the symptomathology of mood disorders in epilepsy is often atypical, intermittent and pleomorphic and fails to meet DSM-...

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Mood disorder and epilepsy: a neurobiologic perspective of their relationship

Mood disorders are the most frequent psychiatric comorbidity in epilepsy, and in particular in temporal lobe epilepsy For a long time, depressive disorders were considered to be the expression of a reactive process to the obstacles of a life with epilepsy. Data obtained in the last two decades, however, have demonstrated biochemical, neuropathological, and neurophysiologic changes mediating the...

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Effect of neurostimulation on cognition and mood in refractory epilepsy

Epilepsy is a common, debilitating neurological disorder characterized by recurrent seizures. Mood disorders and cognitive deficits are common comorbidities in epilepsy that, like seizures, profoundly influence quality of life and can be difficult to treat. For patients with refractory epilepsy who are not candidates for resection, neurostimulation, the electrical modulation of epileptogenic br...

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ژورنال

عنوان ژورنال: Neurology

سال: 2010

ISSN: 0028-3878,1526-632X

DOI: 10.1212/wnl.0b013e3181ed735b